Al Ahly SC will face off with ES Setif in the 2018 CAF Champions League encounter on Tuesday.
Kick-off is at 21h00 CAT.
The semi-final first-leg match will take place at the Al-Salam Stadium in Egypt's capital city, Cairo.
The Egyptian Premier League champions eased into the semi-finals after defeating Guinean club Horoya AC 4-0 on aggregate.
Al Ahly scored four goals in the quarter-final second-leg match at home after the first-leg game ended in a 0-0 draw in Guinea.
Ahmed Fathy, who is one of the longest-serving players in the current Red Devils squad, is a key player for the team.
The defender-cum-midfielder will be looking to inspire Al Ahly to victory in the first-leg encounter.
The Red Devils are the most successful club in the history of the Champions League having won eight titles.
Meanwhile, Setif qualified for the semi-finals after overcoming Moroccan giants Wydad Casablanca 1-0 on aggregate.
The Algerian Professional League side scored the only goal of the quarter-final tie in the first-leg game at home and the second-leg match ended in a 0-0 draw in Morocco.
Islam Dauodi Diomande, who netted the crucial goal for the Black Eagles, is an important player for the team.
The Senegalese defender will be keen to play an important role in helping Setif win in Egypt.
Setif have clinched the Champions League title twice.
Ethiopian match referee Bamlak Tessema Weyesa will officiate the game between Al Ahly and Setif on Tuesday.