Zesco United will welcome Etoile du Sahel in the 2018 CAF Champions League Group D game at the Levy Mwanawasa Stadium in Zambia on Tuesday.
Kick-off is at 15h00 CAT.
The Zambian champions won 3-0 against Swazi side Mbabane Swallows away in their previous Group D game over a week ago.
As a result, they are placed third on the Group D table having accumulated five points from five games. They are a point behind second-placed C.D. Primeiro de Agosto.
Zesco will reach the knockout stages if they beat Etoile and Agosto draw with Swallows.
They have registered two draws, one win and one defeat at home in this year's Champions League.
Meanwhile, Etoile drew 1-1 with Angola's Agosto at home in their previous Group D game over a week ago.
The Tunisian giants are placed at the top of Group D table having accumulated 11 points from five matches. They are five points ahead of second-placed Agosto.
Etoile have already secured their place in the quarter-finals.
They have recorded one draw, one defeat and one win on the road in this year's Champions League.
Match referee Noureddine El Jaafari, who is from Morocco, will be in charge of the game between Zesco v Etoile.
Etoile edged out Zesco 2-1 in a Group D game in Tunisia last May.