Horoya will be out to keep the heat on Mamelodi Sundowns and Wydad Casablanca when they take on AS Togo-Port at the Stade du 28 Septembre in Conakry on Friday evening..
Kick-off is at 18h00 CAT.
The Guinea club currently sit in third place in Group C, level on points with Mamelodi Sundowns with two rounds of fixtures remaining.
Sundowns are away to defending champions Wydad Casablanca at the same time in a clash between the two most recent CAFCL champions.
Knowing that one of the two, or both will drop points in Morocco - Horoya head coach Victor Zvunka has underlined the importance of their clash against the Togolese club ahead of their trip to South Africa on matchday six.
"We have to win the match and then go to South Africa and win to make sure of a place in the quarterfinals," said Zvunka as translated from French.
"But on Friday, it is very important that we win and it is possible, it was our aim from the start and everyone is focused on achieving that goal."
Togo-Port go into their clash against HAC at the bottom of Group C, with three points to their name after four matches.
Horoya beat the Togo club 2-1 in the reverse fixture at the Stade Municipal in Lome back in May, but lost their most recent clash away to Casablanca (2-0) at the end of last month.
Furthermore, the Guinea club have struggled on home soil having accumulated a mere two points in their own backyard following draws against Sundowns (2-2) and Wydad (1-1).
Togo-Port will be hoping for more from their travels, having lost Morocco (3-0) and in South Africa (2-1) in their most recent Group C encounter.
Egyptian referee Gehad Grisha will take charge of the clash in Conakry.