The Barcelona captain has lost in three Copa America finals over the last 12 years, including back-to-back defeats against Chile in the last two editions of South America's premier competition.
With Neymar ruled out of this year's competition hosted in Brazil, Messi will be the star attraction.
Cillessen trying to convince de Ligt to join Barcelona
Having come so close to leading Argentina to FIFA World Cup glory in Brazil five years ago, the 31-year-old is desperate to end his country's hurt in international competitions by lifting the Copa America title at the iconic Maracana next month.
"I want to end my career having won something with the national team, or at least try to do so as many times as possible," he told Fox Sports last week.
Argentina kick-off their campaign against Colombia in Salvador on Saturday.