Despite losing 2-1 away to Nkana in Zambia on Sunday, record three-time Caf Confederations Cup champions CS Sfaxien will be favourites to book their spot in the semi-finals of this year's competition.
Nkana continued their dominance in their own backyard, but will face an uphill task in Sfax if they are to deny their illustrious opponents a place in the final four.
First-leg quarter-final proceedings kicked-off simultaneously in both Kitwe and Nairobi where RS Berkane highlighted their credentials as title contenders.
Kenyan champions Gor Mahia have been a force on their own patch, but the Moroccan's proved too strong as they claimed a 2-0 win away from home.
Etoile du Sahel needed two penalties from Yassine Chikhaoui to beat Al-Hilal Omdurman in Sousse. Athar El Tahir scored what could prove to be a valuable away goal for the Sudanese giant.
In the final game of the day, Hassania Agadir hosted Zamalek in Morocco, but despite dominating most of the game the home side were unable to find the back of the net - leaving themselves a huge task in Cairo this coming weekend.
The reverse fixtures will take place on Sunday, 14 April 2019.
Gor Mahia 0-2 RS Berkane
Nkana 2-1 CS Sfaxien
Etoile du Sahel 3-1 Al-Hilal
Hassania Agadir 0-0 Zamalek