The Brazilians underlined their title credentials with a huge win over the African 'Team of the Century' at a packed Lucas Moripe Stadium on Saturday afternoon, in a Caf Champions League first-leg quarter-final clash.
Not even the most loyal Sundowns supporter would have envisioned what would transpire on the outskirts of the South African capital, as Pitso Mosimane's men dominated from start to finish - humiliating the Egyptian giants who will need a mere miracle if they are to reach the final four.
Themba Zwane, Wayne Arendse, Ricardo Nascimento, Gaston Sirino and Phakamani Mahlambi all found the back of the net in a blowout victory for the 2016 champions, that sent shockwaves across the African continent.
While the match in South Africa proved all action, not the same could be said about the quarter-final showdowns in Tanzania and Guinea where Simba and Horoya were held to respective home draws by African giants TP Mazembe and Wydad Casablanca.
The final game of the day in Algeria between CS Constantine and defending champions Esperance de Tunis would prove to be another classic.
Esperance, who beat Al Ahly in last year's final, went two goals up two minutes after the break, only for the hosts to pull level. The Tunisian's, though, would claim a vital away win as Mohamed Yacoubi struck home the killer blow in a five-goal thriller that leaves Esperance in pole position heading into the reverse fixture.
The second-leg ties of the last eight will take place next Saturday, 13 April 2019.
Mamelodi Sundowns 5-0 Al Ahly
Simba 0-0 TP Mazembe
Horoya 0-0 Wydad Casablanca
Constantine 2-3 Esperance de Tunis