Defending Caf Confederations Cup champions Raja Casablanca and five-time Caf Champions League winners Zamalek enter his weekend's round of CAF CC fixtures in desperate need of a win, if they are to keep their hopes of reaching the knockout stages alive.
The two North African giants currently occupy bottom spot in their respective groups after three rounds of fixtures - having both yet to win a game in this season's competition.
Last year's champions, Raja, fell to a 4-2 defeat at home to RS Berkane last weekend and will now need an away win at their Moroccan rivals on Sunday, if they are to keep any realistic hopes of defending their crown alive.
Zamalek have endured similar troubles throughout the campaign. Despite leading the way in the Egyptian Premier League standings, the White Knights having failed to find their groove on the continent and needed a 94th minute goal from Youssef Obama last time out to conjure a 1-1 draw at home to Petro de Luanda.
The Egyptian giants next face the same opponents in the Angolan capital.
Two-time Caf Confederation Cup champions Etoile du Sahel registered their first win of the group stages last weekend and head into this round of fixtures second in Group B, a point behind record three-time CAFCC champions and Tunisian rivals CS Sfaxien.
It is also a big weekend for ZESCO United and Nkana who are away to Al-Hilal and Asante Kotoko respectively. The Zambian rivals currently occupy first and second place in Group C.
Enugu Rangers vs Etoile du Sahel
Otôho d'Oyo vs Hassania Agadir
Al-Hilal Omdurman vs ZESCO United
Asante Kotoko vs Nkana FC
Petro de Luanda vs Zamalek
Salitas vs CS Sfaxien
RS Berkane vs Raja Casablanca
NA Hussein Dey vs Gor Mahia