Orlando Pirates will square off with the defending champions Esperance de Tunis in the 2018/19 CAF Champions League game on Saturday.
Kick-off is at 21h00 CAT.
The Group B match is scheduled to be played at the Orlando Stadium in the South African city of Johannesburg.
The South African giants secured a 3-0 win over Guinean giants Horoya AC at home in their second Group B game.
The win took Pirates to the top of the group standings with two matches played in the Last 16.
Zambian striker Justin Shonga, who netted twice against Horoya, will be keen to inspire his side to victory against Esperance.
Meanwhile, Esperance secured a 2-0 victory over Zimbabwean champions FC Platinum at home in their opening Group B match.
The victory took the Tunisian champions to the second spot on the group standings and they are only behind leaders Pirates on goal-difference.
Tunisian striker Taha Yassine Khenissi, who netted twice against Platinum, will be looking to score again and help his side win in South Africa.
Ethiopian referee Bamlak Tessema Weyesa will be in charge of the game between Pirates and Esperance.