Wydad Casablanca will face off with ASEC Mimosas in the 2018/19 CAF Champions League Group A match on Friday.
Kick-off is at 21h00 CAT.
The encounter will take place at the Prince Moulay Abdellah Stadium in the Moroccan city of Rabat.
Wydad reached the group stage after edging out Senegalese outfit ASC Diaraf in the first round late last month.
The tie ended in a 3-3 draw on aggregate and the Moroccan Botola League club won on the away goals rule.
Liberian striker Willam Jebor, who netted against Diaraf, will look to score and help his side beat Mimosas.
Meanwhile, Mimosas booked their place in the last 16 after eliminating Malian club Stade Malien in December 2018.
The Côte d'Ivoire Ligue 1 champions beat Stade Malien 2-0 on aggregate - winning 1-0 both home and away.
Mimosas will look to Burkina Faso striker Ahmed Toure, who is a reliable goalscorer for the team.
Senegalese referee Maguette N'Diaye will officiate the match between Wydad and Mimosas.