The Belgian Pro League top four teams failed to collect maximum points on match-day 16.
Zimbabwean midfielder Marvellous Nakamba and his Club Brugge team-mates were stunned 2-0 by Zulte-Waregem on Friday night.
Standard Liege secured a convincing 3-0 win over AS Eupen on Saturday, while KV Oostende lost 3-1 to KV Kortrijk.
Ghanaian defender Joseph Aidoo netted an own as his side, Genk, who are the current log leaders, sucumbed to a 2-1 defeat to Cercle Brugge.
On Sunday, Anderlecht suffered a 4-2 defeat to Sint-Truiden and Gent played to a 0-0 draw with Antwerp.
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Match-day 17 action will be headlined by a clash between Anderlecht and Genk on Sunday.
Gent, who have Nigerian striker Taiwo Awoniyi on their books, will lock horns with Lokeren on Friday in the first game of the weekend.
Sporting Charleroi will play host to Cercle Brugge on Saturday, while Kortrijk are expected to take on Royal Excel Mouscron.
Belgian Pro League fixtures
Kick-off times in CAT
Friday, 30 November
21h30: Lokeren v Gent
Saturday, 1 December
19h00: Sporting Charleroi v Cercle Brugge
21h00: KV Kortrijk v Royal Excel Mouscron
21h00: Zulte-Waregem v KV Oostende
21h30: Antwerp v Sint-Truiden - LIVE on Fox Sports 1 at 21h25 CAT
Sunday, 2 December
15h30: Club Brugge v Standard Liege - LIVE on Fox Sports 2 at 15h25 CAT
19h00: Anderlecht v Genk - LIVE on Fox Sports 1 at 18h55 CAT
21h00: AS Eupen v Waasland-Beveren